| CD247 |
| LOCUS ID | 919 | ||||||||||
| GENE_SYMBOL | CD247 | ||||||||||
| GENE NAME | T-cell surface glyco | ||||||||||
| SYNONYMNS | T3Z, CD3H, CD3Q, CD3Z, TCRZ, IMD25, CD3-ZETA | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 12818 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular sigl-transduction pathways. Low expression of the antigen results in impaired immune response. Two altertively spliced transcript variants encoding distinct isoforms have been found for thi |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. use of CD247 as a biomarker in diabetic patients for evaluating the state of chronic inflammation that contributes to morbidity and mortality in this disease and for the prediction of future cardiovascular events. | 25368105 |