CD28
LOCUS ID940
GENE_SYMBOLCD28
GENE NAMECD28 molecule
SYNONYMNSTp44
CHROMOSOME2
HOMOLOGENE ID4473
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility.22230325
Insulin resistance and inflammation1. Cd28KO epididymal but not subcutaneous fat was characterized by enlarged adipocytes, reduced levels of inflammatory cytokines and increased Glut4, adiponectin and lipogenic enzyme mRNA levels. 25771927