CD36
LOCUS ID948
GENE_SYMBOLCD36
GENE NAMECD36 molecule
SYNONYMNSFAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3, BDPLT10
CHROMOSOME7
HOMOLOGENE ID73871
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. eNOS and CD34 expression was upregulated in H. pylori-positive controls but not in H. pylori-positive diabetic patients (p=0.010 and 0.007 for the corpus and p=0.036 and 0.047 for the antrum, respectively).15737001 , 25619588
Cardiovascular1. Our provide evidence that up-regulation of CD36 may have a role in increasing oxidative stress in microvascular endothelial cells (MVECs) and the heart in chronic diabetes.15915335
Atherosclerosis1. Incubation of monocytes with AGE + bovine serum albumin (BSA), CD36 expression and intracellular ROS increased significantly in all groupsAdvanced glycation end products (AGEs) engagement of a monocyte surface receptor (RAGE) induces atherosclerosis. AGEs also act as CD36 ligands.Blocking RAGE expression using siRNA in human monocytes led to a significant inhibition of CD36 expression and ROS production, suggesting a positive interaction between RAGE, CD36 expression and ROS generation in monocytes.19190027