CD63
LOCUS ID967
GENE_SYMBOLCD63
GENE NAMECD63 molecule
SYNONYMNSMLA1, ME491, LAMP-3, OMA81H, TSPAN30
CHROMOSOME12
HOMOLOGENE ID37526
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Altertive splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Concentrations of sE-selectin were higher in Type II diabetes patients than in control subjects, and correlated with MDMP, PDMP, plt-CD62P, and plt-CD63 levels in nephropathy patients.12032632