CD68
LOCUS ID968
GENE_SYMBOLCD68
GENE NAMECD68 molecule
SYNONYMNSGP110, LAMP4, SCARD1
CHROMOSOME17
HOMOLOGENE ID955
microRNAsNANA
GENE SUMMARY
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Altertive splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. While IL6, CCL2 and CCR5-mR, and CD68 were overexpressed in the tubulointerstitial compartment in clinical DN, they were not expressed in microalbuminuria.24786705