| CD68 |
| LOCUS ID | 968 | ||||||||||||||||
| GENE_SYMBOL | CD68 | ||||||||||||||||
| GENE NAME | CD68 molecule | ||||||||||||||||
| SYNONYMNS | GP110, LAMP4, SCARD1 | ||||||||||||||||
| CHROMOSOME | 17 | ||||||||||||||||
| HOMOLOGENE ID | 955 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. While IL6, CCL2 and CCR5-mR, and CD68 were overexpressed in the tubulointerstitial compartment in clinical DN, they were not expressed in microalbuminuria. | 24786705 |
| Cardiovascular | 1. LOX-1 and CD68 and were higher in IHD patients with T2DM and were identified as a cardiovascular risk factor of T2DM. | 30894181 |
| Insulin resistance and inflammation | 1. CD68 expression and serum TNFalpha concentrations were correlated with insulin resistance. | 16608891 |