CD74
LOCUS ID972
GENE_SYMBOLCD74
GENE NAMECD74 molecule, major histocompatibility complex, class II invariant chain
SYNONYMNSII, DHLAG, HLADG, Ia-GAMMA
CHROMOSOME5
HOMOLOGENE ID3209
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple altertively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These data suggest that CD74 acts as a receptor for MIF in podocytes and may play a role in the pathogenesis of diabetic nephropathy.18842989