CDH1
LOCUS ID999
GENE_SYMBOLCDH1
GENE NAMEcadherin 1, type 1
SYNONYMNSUVO, CDHE, ECAD, LCAM, Arc-1, CD324
CHROMOSOME16
HOMOLOGENE ID20917
microRNAsNANA
GENE SUMMARY
This gene encodes a classical cadherin of the cadherin superfamily. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for interlization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We provide compelling evidence that TGF-beta 1-induced EMT instigates a loss of E-cadherin, cell adhesion and ultimately of connexin-mediated cell communication in the proximal tubule under diabetic conditions; these changes occur ahead of overt signs of renal damage. 2. Decreased expression of P- and E-cadherins is implicated in podocyte dysfunction and epithelial-mesenchymal transition observed in DN. We speculate that the actions of GH on ZEB2 and P- and E-cadherin expression play a role in the pathogenesis of microalbuminuria of DN.22215279 , 20682777