CDH2
LOCUS ID1000
GENE_SYMBOLCDH2
GENE NAMEcadherin 2, type 1, N-cadherin (neurol)
SYNONYMNSCDHN, NCAD, CD325, CDw325
CHROMOSOME18
HOMOLOGENE ID20424
microRNAsNANA
GENE SUMMARY
This gene encodes a classical cadherin and member of the cadherin superfamily. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. It was shown that CTGF, MCP-1, PAI-1, ACE, CDH1, CDH2 mRNA varied significantly among the 3 study groups, and their mRNA levels increased with DN progression (p<0.05).22629296