CDKN1A
LOCUS ID1026
GENE_SYMBOLCDKN1A
GENE NAMEcyclin-dependent kinase inhibitor 1A (p21, Cip1)
SYNONYMNSP21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1
CHROMOSOME6
HOMOLOGENE ID333
microRNAsNANA
GENE SUMMARY
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PC), a D polymerase accessory factor, and plays a regulatory role in S phase D replication and D damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple altertively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. At the cell-cycle level, the HG-induced proliferation of MCs was associated with a decrease in cyclin dependent kinase (CDK) inhibitor p21 protein expression accompanied by an increase in CDK4 and CDK2 kinase activities. 2. The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathypotential role in glomerular hypertroph These results support a role for p21 in causing glomerular cell hypertrophy in diabetic nephropathy.12048257