CDKN2A
LOCUS ID1029
GENE_SYMBOLCDKN2A
GENE NAMEcyclin-dependent kin
SYNONYMNSARF, MLM, P14, P16, P19,
CHROMOSOME9
HOMOLOGENE ID55430
microRNAsNANA
GENE SUMMARY
This gene generates several transcript variants which differ in their first exons. At least three altertively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alterte first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alterte open reading frame (ARF) that specifies a protein which is structurally unrelated t

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk.23298195
AtherosclerosisThus, atherosclerosis complications in T2DM associate with altered immune cell homeostasis, diminished CDKN2A/2B/2BAS expression, and increased CDK4 levels. The present study also suggests that the treatment with drugs that mimic CDKN2A/2B genes could potential be considered as a promising therapy to delay atherosclerosis.30176239