| CETP |
| LOCUS ID | 1071 | ||||||||||||||||
| GENE_SYMBOL | CETP | ||||||||||||||||
| GENE NAME | cholesteryl ester tr | ||||||||||||||||
| SYNONYMNS | BPIFF, HDLCQ10 | ||||||||||||||||
| CHROMOSOME | 16 | ||||||||||||||||
| HOMOLOGENE ID | 47904 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Our study suggests that candidate gene polymorphism -629C>A of CETP may serve as a susceptibility biomarker for CVD in T2DM patients. Analyzing the combined effect of both ACE and CETP genotypes would enhance the sensitivity and specificity of CVD risk estimation in the T2DM patients in our population | 21185205 |
| Atherosclerosis | 1. increase in CETP under diabetic conditions might be a major factor responsible for increased incidence of diabetes-induced atherosclerosis. | 14608418 |
| Dyslipidemia | 1. CETP was intimately involved in dyslipidemia-related susceptibility to cognitive decline, especially memory function in type 2 diabetic patients. | 27497473 |