CHIT1
LOCUS ID1118
GENE_SYMBOLCHIT1
GENE NAMEchitinase 1
SYNONYMNSCHI3,CHIT,CHITD
CHROMOSOME1
HOMOLOGENE ID68318
microRNAsNANA
GENE SUMMARY
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The immunomodulatory effects of chitotriosidase enzyme could be implicated in the development of nephropathy in type 2 diabetes.26589000