CISH
LOCUS ID1154
GENE_SYMBOLCISH
GENE NAMEcytokine inducible SH2-containing protein
SYNONYMNSCIS, G18, SOCS, CIS-1, BACTS2
CHROMOSOME3
HOMOLOGENE ID7667
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine sigling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the ictivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Suppressor of cytokine signaling (SOCS) 2 attenuates renal lesions in rats with diabetic nephropathy.Additionally, adenovirus-mediated upregulation of renal SOCS2 markedly inhibited STZ-induced phosphorylation increases of Janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3, STAT5 and extracellular receptor-activated kinase (ERK) 1/2. the present research demonstrates that SOCS2 reduces renal lesions associated with diabetes in rats. 2. Usin DNA microarray analysis of glomerular R from control and diabetic rats we found that the expression levels of insulin-like growth factor 1 receptor (IGF-1R) were increased while those of suppressor of cytokine signaling 2 (SOCS2) and STAT5 were decreased.24802166 , 19008912