| CMA1 |
| LOCUS ID | 1215 | ||||||||||
| GENE_SYMBOL | CMA1 | ||||||||||
| GENE NAME | chymase 1, mast cell | ||||||||||
| SYNONYMNS | CYH, MCT1, chymase | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 55606 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene product is a chymotryptic serine proteise that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicate |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. This study suggests that mast cells are involved in development of diabetic nephropathy. Through release of bioactive substances, such as tryptase, chymase, TGF-beta1, renin and TNF-alpha, into the tubular interstitium by degranulation, mast cells could promote renal inflammation and fibrosis, and thus contribute to diabetic nephropathy. | 22130579 |