CMC4
LOCUS ID100272147
GENE_SYMBOLCMC4
GENE NAMEC-x(9)-C motif conta
SYNONYMNSp8, C6.1B, MTCP1, MTCP1B, MTCP1NB, p8MTCP1
CHROMOSOMEX
HOMOLOGENE ID106257
microRNAsNANA
GENE SUMMARY
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the downstream 8 kDa protein that localizes to mitochondria.

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Our transcriptional profiling studies have revealed that the p8 gene, which encodes a putative basic helix-loop-helix protein, is strongly induced in ET-1-treated renal mesangial cells and in an animal model of diabetic nephropathy 2. Thus, p8 is a novel marker for diabetic renal hypertropy.15016802