CNDP1
LOCUS ID84735
GENE_SYMBOLCNDP1
GENE NAMEcarnosine dipeptidase 1 (metallopeptidase M20 family)
SYNONYMNSCN1, CPGL2, HsT2308
CHROMOSOME18
HOMOLOGENE ID57178
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. polymorphisms within the carnosine dipeptidase 1 gene (CNDP1), located on 18q22. 3, have been shown to be associated with diabetic nephropathy in European subjects with type 2 diabetes.23342076
Cardiovascular1. There was a significant interaction between CNDP1 and sex for the association with cardiovascular mortality (p = 0.01), not for all-cause mortality (p = 0.32). The association between CNDP1 and cardiovascular mortality was sex-specific, with a higher risk in women with 5L-5L genotype.24756973