| CNR1 |
| LOCUS ID | 1268 | ||||||||||||||||
| GENE_SYMBOL | CNR1 | ||||||||||||||||
| GENE NAME | canbinoid receptor 1 | ||||||||||||||||
| SYNONYMNS | CB1, CNR, CB-R, CB1A, CB1R, CANN6, CB1K5 | ||||||||||||||||
| CHROMOSOME | 6 | ||||||||||||||||
| HOMOLOGENE ID | 7273 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes one of two canbinoid receptors. The canbinoids, principally delta-9-tetrahydrocanbinol and synthetic alogs, are psychoactive ingredients of marijua. The canbinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the canbinoid-induced CNS effects (including alter |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. We investigated a role of the polymorphism in CNR1 gene in type 2 diabetes and its complications.The novel finding of our study is the association of the CNR1 G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM | 24075694 |
| Retinopathy | 1. The novel finding of our study is the association of the CNR1 G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM | 24075694 |
| Neuropathy | 1. When initiated in an established DPN NeP state, both CB1 and CB2 agonists demonstrated an antinociceptive effect until their discontinuation. | 20236533 |