CNR1
LOCUS ID1268
GENE_SYMBOLCNR1
GENE NAMEcanbinoid receptor 1 (brain)
SYNONYMNSCB1, CNR, CB-R, CB1A, CB1R, CANN6, CB1K5
CHROMOSOME6
HOMOLOGENE ID7273
microRNAsNANA
GENE SUMMARY
This gene encodes one of two canbinoid receptors. The canbinoids, principally delta-9-tetrahydrocanbinol and synthetic alogs, are psychoactive ingredients of marijua. The canbinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the canbinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijua. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We investigated a role of the polymorphism in CNR1 gene in type 2 diabetes and its complications.The novel finding of our study is the association of the CNR1 G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM24075694
Retinopathy1. The novel finding of our study is the association of the CNR1 G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM24075694
Neuropathy1. When initiated in an established DPN NeP state, both CB1 and CB2 agonists demonstrated an antinociceptive effect until their discontinuation.20236533