| COLEC12 |
| LOCUS ID | 81035 | ||||||||||
| GENE_SYMBOL | COLEC12 | ||||||||||
| GENE NAME | collectin subfamily | ||||||||||
| SYNONYMNS | CLP1, NSR2, SRCL, SCARA4 | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 34248 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, interlization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. | 25819896 |