COLEC12
LOCUS ID81035
GENE_SYMBOLCOLEC12
GENE NAMEcollectin subfamily member 12
SYNONYMNSCLP1, NSR2, SRCL, SCARA4
CHROMOSOME18
HOMOLOGENE ID34248
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, interlization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.25819896