CORO1A
LOCUS ID11151
GENE_SYMBOLCORO1A
GENE NAMEcoronin 1A
SYNONYMNSp57, IMD8, TACO, CLABP, HCORO1, CLIPINA
CHROMOSOME16
HOMOLOGENE ID6545
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. Repression of RXR gene could hamper VDR-RXR heterodimer formation and thus would up regulate TACO gene expression which may predispose the type-2 DM patients to tuberculosis. 26089620