CRK
LOCUS ID1398
GENE_SYMBOLCRK
GENE NAMEv-crk avian sarcoma virus CT10 oncogene homolog
SYNONYMNSp38, CRKII
CHROMOSOME17
HOMOLOGENE ID81850
microRNAsNANA
GENE SUMMARY
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway. The activity of AP-1, a transcription factor complex that regulates several genes involved in diabetic nephropathy, is reversed when the p38 MAPK pathway is inhibited. These findings suggest the p38 MAPK pathway may be an important pathway involved in diabetic complications.11532081
Cardiovascular1. p38 mitogen-activated protein kinase is a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.19275680
Retinopathy1.Some of the diabetic mice were treated with inhibitors of receptor for advanced glycation endproducts (RAGE) and p38 mitogen activated protein (MAP) kinase, which have previously been shown to inhibit diabetic retinopathy in rodent models. 2. Both the anti-inflammatory and anti-apoptotic effects of glucocorticoids may be mediated through inhibition of the p38 MAPK pathway in diabetic retinopathy. 3. This study was conducted to evaluate the effect of a p38 MAPK inhibitor on the development of early stages of diabetic retinopathy in rats22605924 , 23745583,20071676
Atherosclerosis1. PCs seem to participate in plaque formation and progression.Since Polycystins (PC)-1 upregulation coincides with p38 and p53 activation, a potential interplay of these molecules in atherosclerosis induction is posed.26286632
Neuropathy1. Increased p38 mitogen-activated protein kinase (MAPK) in response to stress stimuli, including hyperglycemia, contributes to diabetic somatic neuropathy.16355109