CRP
LOCUS ID1401
GENE_SYMBOLCRP
GENE NAMEC-reactive protein, pentraxin-related
SYNONYMNSPTX1
CHROMOSOME1
HOMOLOGENE ID128039
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimition by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Elevated serum MBL in T2DM patients indicated a possible poor diabetic control and bad progression of the disease with possibility of the presence, or development of diabetic nephropathy especially incombination with elevated serum CRP.21858386
Cardiovascular1. Our findings emphasize that diabetics were 5.6 times more likely to have high CRP levels than nondiabetics; as CRP is a predictor of cardiovascular disease risk, it can be recognized that diabetics are at more risk of cardiovascular disease than nondiabetics.26379442
Retinopathy1. The serum ischemia modified albumin (IMA) and hs-CRP concentration were significantly high in DR patients, and were positively associated with the seriousness of DR, which may contribute to the development of DR. 2. The results obtained in the present study indicate that type 2 diabetic patients with higher levels of CRP, TNF- alpha and VEGF were likely to develop diabetic retinopathy, with significant association found in patients with proliferative diabetic retinopathy.20137285, 28420575
Atherosclerosis1. Serum hs-CRP levels on admission in patients with acute coronary syndrome (ACS) could predict the severity and complexity of coronary atherosclerosis together with multivessel disease, LVEF, and troponin levels.26118590
Neuropathy1. High levels of C-reactive protein and interleukin (IL)-6 were most consistently associated with diabetic polyneuropathy, high MNSI score, and specific neuropathic deficits, whereas some inverse associations were seen for IL-18. This study shows that subclinical inflammation is associated with diabetic polyneuropathy and neuropathic impairments. This association appears rather specific because only certain immune mediators and impairments are involved.19131463