CTSH
LOCUS ID1512
GENE_SYMBOLCTSH
GENE NAMEcathepsin H
SYNONYMNSACC4, ACC5, CPSB, ACC-4, ACC-5, minichain
CHROMOSOME15
HOMOLOGENE ID36159
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a lysosomal cysteine proteise important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignt progression of prostate tumors. Alterte splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. In , CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to PDR and two-step progression of DR on the ETDRS scale accordingly.26245339