| CTSS |
| LOCUS ID | 1520 | ||||||||||
| GENE_SYMBOL | CTSS | ||||||||||
| GENE NAME | cathepsin S | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 20867 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteise that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Altertively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Unsurprisingly, mis-regulation has implicated cathepsin S in a variety of pathological processes including arthritis, cancer, and cardiovascular disease, where it becomes secreted and can act on extracellular substrates. | 25872877 |