CX3CL1
LOCUS ID6376
GENE_SYMBOLCX3CL1
GENE NAMEchemokine (C-X3-C motif) ligand 1
SYNONYMNSNTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fra
CHROMOSOME16
HOMOLOGENE ID2251
microRNAsNANA
GENE SUMMARY
NA

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Fractalkine and CX3CR1 upregulation were demonstrated in an early stage of diabetic kidney. These upregulation, as well as urinary albumin excretion, were suppressed by treatments with temocapril and aminoguanidine for 8 weeks. These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy.15153757
Cardiovascular1. Circulating CX3CL1 level may contribute to both atherosclerotic CVD and diabetes in a CKD cohort.25795074