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CX3CL1 |
LOCUS ID | 6376 | |||||||||||||
GENE_SYMBOL | CX3CL1 | |||||||||||||
GENE NAME | chemokine (C-X3-C motif) ligand 1 | |||||||||||||
SYNONYMNS | NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fra | |||||||||||||
CHROMOSOME | 16 | |||||||||||||
HOMOLOGENE ID | 2251 |
microRNAs | NA | NA |
GENE SUMMARY |
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NA |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. Fractalkine and CX3CR1 upregulation were demonstrated in an early stage of diabetic kidney. These upregulation, as well as urinary albumin excretion, were suppressed by treatments with temocapril and aminoguanidine for 8 weeks. These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy. | 15153757 |
Cardiovascular | 1. Circulating CX3CL1 level may contribute to both atherosclerotic CVD and diabetes in a CKD cohort. | 25795074 |