| CX3CL1 |
| LOCUS ID | 6376 | |||||||||||||
| GENE_SYMBOL | CX3CL1 | |||||||||||||
| GENE NAME | chemokine (C-X3-C motif) ligand 1 | |||||||||||||
| SYNONYMNS | NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fra | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 2251 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| NA |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Fractalkine and CX3CR1 upregulation were demonstrated in an early stage of diabetic kidney. These upregulation, as well as urinary albumin excretion, were suppressed by treatments with temocapril and aminoguanidine for 8 weeks. These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy. | 15153757 |
| Cardiovascular | 1. Circulating CX3CL1 level may contribute to both atherosclerotic CVD and diabetes in a CKD cohort. | 25795074 |