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CXCL10 |
LOCUS ID | 3627 | |||||||||||||
GENE_SYMBOL | CXCL10 | |||||||||||||
GENE NAME | chemokine (C-X-C motif) ligand 10 | |||||||||||||
SYNONYMNS | C7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10 | |||||||||||||
CHROMOSOME | 4 | |||||||||||||
HOMOLOGENE ID | 1203 |
microRNAs | NA | NA |
GENE SUMMARY |
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This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. while IL-10, CXCL8, CXCL9, CXCL10 and adiponectin concentrations of DN were significantly higher than patients without diabetic nephropathy (NDN) and control subjects (all P < 0.05). | 17425653 |
Neuropathy | 1. RT-PCR demonstrated that elevated levels of mRNA of CCL2, CXCL10 or TLR4 in the spinal cord of DM mice decreased significantly when DM mice were treated with CoQ10. | 23684663 |