CXCL10
LOCUS ID3627
GENE_SYMBOLCXCL10
GENE NAMEchemokine (C-X-C motif) ligand 10
SYNONYMNSC7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10
CHROMOSOME4
HOMOLOGENE ID1203
microRNAsNANA
GENE SUMMARY
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. while IL-10, CXCL8, CXCL9, CXCL10 and adiponectin concentrations of DN were significantly higher than patients without diabetic nephropathy (NDN) and control subjects (all P < 0.05).17425653
Neuropathy1. RT-PCR demonstrated that elevated levels of mRNA of CCL2, CXCL10 or TLR4 in the spinal cord of DM mice decreased significantly when DM mice were treated with CoQ10.23684663