| CXCL10 |
| LOCUS ID | 3627 | |||||||||||||
| GENE_SYMBOL | CXCL10 | |||||||||||||
| GENE NAME | chemokine (C-X-C motif) ligand 10 | |||||||||||||
| SYNONYMNS | C7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10 | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 1203 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. while IL-10, CXCL8, CXCL9, CXCL10 and adiponectin concentrations of DN were significantly higher than patients without diabetic nephropathy (NDN) and control subjects (all P < 0.05). | 17425653 |
| Neuropathy | 1. RT-PCR demonstrated that elevated levels of mRNA of CCL2, CXCL10 or TLR4 in the spinal cord of DM mice decreased significantly when DM mice were treated with CoQ10. | 23684663 |