CXCL11
LOCUS ID6373
GENE_SYMBOLCXCL11
GENE NAMEchemokine (C-X-C motif) ligand 11
SYNONYMNSIP9, H174, IP-9, b-R1, I-TAC, SCYB11, SCYB9B
CHROMOSOME4
HOMOLOGENE ID3944
microRNAsNANA
GENE SUMMARY
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the domint ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation sigls which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Urinary mRNA levels of CXCL10 and CXCL11 are decreased, and those of collagen I A1 chain and fibronectin are increased in diabetic nephropathy.25865428