| CXCL8 |
| LOCUS ID | 3576 | |||||||||||||
| GENE_SYMBOL | CXCL8 | |||||||||||||
| GENE NAME | chemokine (C-X-C mot | |||||||||||||
| SYNONYMNS | IL8, F, GCP1, LECT, LUCT, P1, GCP-1, LYP, MDNCF, MOP, P-1 | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 47937 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cl |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. 2. These suggest that these three CXC chemokines may be involved in the progression of human Type 2 diabetic nephropathy and that CXCL5 may be of use for telling diabetic nephropathy from primary renal diseases. | 18413205 |
| Insulin resistance and inflammation | 1. IL-8 and TNF-? correlated positively with macrophage markers including CD68, CD163 and CD86 in adipose tissue. These findings suggest that the signaling cross-talk between saturated fatty acid palmitate and TNF-? may be a key driver in obesity-associated chronic inflammation via an excessive production of IL-8. | 31443599 |