CXCL8
LOCUS ID3576
GENE_SYMBOLCXCL8
GENE NAMEchemokine (C-X-C motif) ligand 8
SYNONYMNSIL8, F, GCP1, LECT, LUCT, P1, GCP-1, LYP, MDNCF, MOP, P-1
CHROMOSOME4
HOMOLOGENE ID47937
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. 2. These suggest that these three CXC chemokines may be involved in the progression of human Type 2 diabetic nephropathy and that CXCL5 may be of use for telling diabetic nephropathy from primary renal diseases.18413205