| CYP24A1 |
| LOCUS ID | 1591 | ||||||||||
| GENE_SYMBOL | CYP24A1 | ||||||||||
| GENE NAME | cytochrome P450, fam | ||||||||||
| SYNONYMNS | CP24, HCAI, CYP24, P450-CC24 | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 68094 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygeses which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitam |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. diabetes induces an increase in CYP24A1 expression, destabilizing vitamin D metabolism in the renal proximal tubules, leading to cellular instability and apoptosis, and thereby accelerating tubular injury progression during diabetic nephropathy. | 23119081 |