| CYP2C18 |
| LOCUS ID | 1562 | ||||||||||
| GENE_SYMBOL | CYP2C18 | ||||||||||
| GENE NAME | cytochrome P450 fami | ||||||||||
| SYNONYMNS | CPCI CYP2C CYP2C17 P450IIC17 P450-6B/29C | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 1562 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. These alterations induced by Type II diabetes in the endogenous pathway (CYP450) of arachidonic acid metabolism may increase the risk for cardiovascular disease by disrupting the fine equilibrium between cardioprotective (CYP2J/CYP2C-generated) and cardiotoxic (CYP4A/CYP4F-generated) metabolites of arachidonic acid. | 29023376 |