CYP2C19
LOCUS ID1557
GENE_SYMBOLCYP2C19
GENE NAMEcytochrome P450 family 2 subfamily C member 19
SYNONYMNSCPCJ, CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19
CHROMOSOME10
HOMOLOGENE ID133565
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygeses which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The CYP2C19 poor metabolizer genotype was found to be an independent risk factor for DR only in women when patients were stratified by sex (OR, 4.18; 95% CI, 1.42-12.26).24113215