CYR61
LOCUS ID3491
GENE_SYMBOLCYR61
GENE NAMEcysteine rich angiogenic inducer 61
SYNONYMNSCCN1, GIG1, IGFBP10
CHROMOSOME1
HOMOLOGENE ID1194
microRNAsNANA
GENE SUMMARY
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. In mice infused with exogenous AGE, Cyr61 expression increased fourfold and Ctgf expression increased twofold in the retina.CTGF and CYR61 are downstream effectors of AGE in the diabetic retina, implicating them as possible targets for future intervention strategies against the development of diabetic retinopathy17333105