DCN
LOCUS ID1634
GENE_SYMBOLDCN
GENE NAMEdecorin
SYNONYMNSCSCD, PG40, PGII, PGS2, DSPG2, SLRR1B
CHROMOSOME12
HOMOLOGENE ID22430
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Decorin, a protein similar to podocan, also belongs to the SLRP family and is highly expressed in adipose tissues. It is associated with obesity, type 2 diabetes, and diabetic nephropathy.29264529