DDAH1
LOCUS ID23576
GENE_SYMBOLDDAH1
GENE NAMEdimethylarginine dimethylaminohydrolase 1
SYNONYMNSDDAH, HEL-S-16
CHROMOSOME1
HOMOLOGENE ID8120
microRNAsNANA
GENE SUMMARY
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The present study demonstrated for the first time that the suppression of ADMA by DDAH overexpression could improve tubulointerstitial ischaemia and subsequent renal damage in experimental diabetic nephropathy. 2. Substitution of DDAH protein or enhancement of its activity may become a novel therapeutic strategy for the treatment of early diabetic nephropathy.19015171
Retinopathy1. It can be concluded that PRMT-I and DDAHs-induced upregulation of ADMA levels might be involved in ROS- and RAS-mediated diabetic retinopathy.19748504