DDR1
LOCUS ID780
GENE_SYMBOLDDR1
GENE NAMEdiscoidin domain rec
SYNONYMNSCAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, CD167, EDDR1, MCK10, NTRK4, PTK3A
CHROMOSOME6
HOMOLOGENE ID68212
microRNAsNANA
GENE SUMMARY
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. These novel findings demonstrate that DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling.29930002
Insulin resistance and inflammation1. ?HNF-4? binds to the cis-type element DR1 in the SHBG promoter to initiate transcription and regulates hepatic SHBG levels by modulating glucose and lipid metabolism and inflammatory factors. 31525346