DPP4
LOCUS ID1803
GENE_SYMBOLDPP4
GENE NAMEdipeptidyl-peptidase 4
SYNONYMNSCD26, ADABP, ADCP2, DPPIV, TP103
CHROMOSOME2
HOMOLOGENE ID3279
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. This study shows that increased DPP4 activities are strongly and independently associated with diabetic nephropathy in type 2 diabetes. The associations between DPP4 and diabetic nephropathy, although strong, do not imply causality.26821795
Cardiovascular1. Recently, a novel receptor for soluble DPP4 has been identified, and data are accumulating that the adipokine-related effects of DPP4 may play an important role in the pathogenesis of cardiovascular disease.26284071
Atherosclerosis1. This study shows that increased DPP4 activities are positively and independently associated with subclinical atherosclerosis in type 2 diabetes.26318108
Retinopathy1. These findings indicated that serum LECT2 level is negatively associated with the presence of DR and suggest that low circulating LECT2 level is a risk factor for DR.27816666