EBF2
LOCUS ID64641
GENE_SYMBOLEBF2
GENE NAMEearly B-cell factor 2
SYNONYMNSCOE2, OE-3, EBF-2, O/E-3
CHROMOSOME8
HOMOLOGENE ID56471
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved D binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We demonstrate upregulation of the Knot ortholog EBF2 in glomeruli of human diabetic nephropathy patients and a mouse ob/ob diabetes model.26190114