| EDNRA |
| LOCUS ID | 1909 | ||||||||||
| GENE_SYMBOL | EDNRA | ||||||||||
| GENE NAME | endothelin receptor | ||||||||||
| SYNONYMNS | ETA, ET-A, ETAR, ETRA, MFDA, ETA-R, hET-AR | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 1478 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. | 17167119 |