EDNRA
LOCUS ID1909
GENE_SYMBOLEDNRA
GENE NAMEendothelin receptor type A
SYNONYMNSETA, ET-A, ETAR, ETRA, MFDA, ETA-R, hET-AR
CHROMOSOME4
HOMOLOGENE ID1478
microRNAsNANA
GENE SUMMARY
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism.17167119