EGFR
LOCUS ID1956
GENE_SYMBOLEGFR
GENE NAMEepidermal growth factor receptor
SYNONYMNSERBB, HER1, mE, ERBB1, PIG61, NISBD2
CHROMOSOME7
HOMOLOGENE ID74545
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. EGFR inhibition may be a therapeutic strategy in the treatment of diabetic nephropathy and in limiting salt and water retention, which currently restricts the use of PPA gamma agonists.23370527
Cardiovascular1. Human epidermal growth factor receptor 2 (HER2) status, hypertension, and coronary artery disease were significant predictors for both heart failure groups (p< 0.001). Type II diabetes was a risk factor for the late-onset AIHF group (p<0.001).HER2 status and cardiovascular risk factors increased the risk of heart failure among doxorubicin users. Patients with type II diabetes were at increased risk of late-onset anthracycline-induced heart failure (AIHF).25342090