EIF4EBP1
LOCUS ID1978
GENE_SYMBOLEIF4EBP1
GENE NAMEeukaryotic translation initiation factor 4E binding protein 1
SYNONYMNSBP-1, 4EBP1, 4E-BP1, PHAS-I
CHROMOSOME8
HOMOLOGENE ID3021
microRNAsNANA
GENE SUMMARY
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various sigls including UV irradiation and insulin sigling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These findings suggest the possibility that resveratrol exerts antiproliferative, antihypertrophic effects by activating AMPK and reducing 4E-BP1 and S6 phosphorylation, thus suppressing the development and progression of DN.20332614