ELMO1
LOCUS ID9844
GENE_SYMBOLELMO1
GENE NAMEengulfment and cell motility 1
SYNONYMNSCED12, CED-12, ELMO-1
CHROMOSOME7
HOMOLOGENE ID56685
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. This study first investigated the association of ELMO1 gene polymorphisms with DN in a Chinese population, supporting its key role as a candidate gene in the susceptibility of DN.20019166