ENPP2
LOCUS ID5168
GENE_SYMBOLENPP2
GENE NAMEectonucleotide pyrophosphatase/phosphodiesterase 2
SYNONYMNSATX, NPP2, ATX-X, PDNP2, LysoPLD, AUTOTAXIN, PD-IALPHA
CHROMOSOME8
HOMOLOGENE ID4526
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several altertively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. ATX is a multifunctional ectoenzyme and is involved in many patho-physiological conditions such as cancer, neuropathy pain, lymphocyte tracking in lymph nodes, obesity, diabetes and embryonic blood vessel formation. 2. In serum or plasma, LPA is predomintly produced by a plasma enzyme called autotaxin (ATX). ATX is a multifunctional ectoenzyme and is involved in many patho-physiological conditions such as cancer, neuropathy pain, lymphocyte tracking in lymph nodes, obesity, diabetes and embryonic blood vessel formation.18621144