EPO
LOCUS ID2056
GENE_SYMBOLEPO
GENE NAMEerythropoietin
SYNONYMNSEP, MVCD2
CHROMOSOME7
HOMOLOGENE ID624
microRNAsNANA
GENE SUMMARY
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. EPO and Hb x EPO values may be a new marker predicting future chronic renal failure in diabetic overt nephropathy.9127329 , 19095759
Retinopathy1. We conclude that EPO may play a primary role against the progression of diabetic retinopathy by reducing blood vessel degeneration at a very early disease stage23178551
Neuropathy1. Autonomic neuropathy is associated with a blunted EPO response to anemia in type 2 diabetic patients without advanced renal failure.19303331