ERAP2
LOCUS ID64167
GENE_SYMBOLERAP2
GENE NAMEendoplasmic reticulum aminopeptidase 2
SYNONYMNSLRAP, L-RAP
CHROMOSOME5
HOMOLOGENE ID75183
microRNAsNANA
GENE SUMMARY
Aminopeptidases hydrolyze N-termil amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The recombint adenovirus expressing shRNA effectively silencing LRAP gene was constructed successfully, which would facilitate further study of the role that LRAP plays in the development of diabetic retinopathy22980650