ERBB2
LOCUS ID2064
GENE_SYMBOLERBB2
GENE NAMEerb-b2 receptor tyrosine kinase 2
SYNONYMNSNEU, NGL, HER2, TKR1, CD340, HER-2, MLN, 19, HER-2/neu
CHROMOSOME17
HOMOLOGENE ID3273
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream siglling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Altertive splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. HER2 status and cardiovascular risk factors increased the risk of heart failure among doxorubicin users.25342090
Neuropathy1. Increased Erb B2 activity contributes to specific indexes of DPN, and Cav1 may be an endogenous regulator of Erb B2 signaling.19675140