ERCC4
LOCUS ID2072
GENE_SYMBOLERCC4
GENE NAMEexcision repair cross-complementation group 4
SYNONYMNSXPF, RAD1, FANCQ, ERCC11
CHROMOSOME16
HOMOLOGENE ID3836
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific D repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. ERCC1 and ERCC4 may play important roles in the development of diabetic retinopathy and nephropathy.22228707
Retinopathy1. ERCC1 and ERCC4 may play important roles in the development of diabetic retinopathy and nephropathy.22228707