ESM1
LOCUS ID11082
GENE_SYMBOLESM1
GENE NAMEendothelial cell specific molecule 1
SYNONYMNSendocan
CHROMOSOME5
HOMOLOGENE ID5107
microRNAsNANA
GENE SUMMARY
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Apelin,endoglin and endocan might be associated with endothelial dysfunction,angiogenesis and inflammation mechanism which play some role in DPN pathogenesis.27010147