| EZR |
| LOCUS ID | 7430 | ||||||||||
| GENE_SYMBOL | EZR | ||||||||||
| GENE NAME | ezrin | ||||||||||
| SYNONYMNS | CVL, CVIL, VIL2, HEL-S-105 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 55740 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Altertively splice |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These show a role for ezrin in AGE-induced podocyte damage and suggest a new avenue for possible therapeutic intervention in diabetic nephropathy. | 26032400 |