EZR
LOCUS ID7430
GENE_SYMBOLEZR
GENE NAMEezrin
SYNONYMNSCVL, CVIL, VIL2, HEL-S-105
CHROMOSOME6
HOMOLOGENE ID55740
microRNAsNANA
GENE SUMMARY
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Altertively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These show a role for ezrin in AGE-induced podocyte damage and suggest a new avenue for possible therapeutic intervention in diabetic nephropathy.26032400