FABP4
LOCUS ID2167
GENE_SYMBOLFABP4
GENE NAMEfatty acid binding protein 4 adipocyte
SYNONYMNSaP2, ALBP, AFABP, A-FABP, HEL-S-104
CHROMOSOME8
HOMOLOGENE ID36067
microRNAsNANA
GENE SUMMARY
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small highly conserved cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake transport and metabolism. [provided by RefSeq Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. we found high serum A-FABP4 but unchanged RBP4 concentrations and their associations with renal function and early diabetic nephropathy in type 2 DM.18305958
Cardiovascular1. These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus.20920650
Atherosclerosis1. FABP4 up-regulation is responsible for the enhanced macrophage lipid accumulation by AGE, which may underlie the accelerated formation of foam cells and development of atherosclerotic cardiovascular diseases in diabetic patients.21336983