FABP4
LOCUS ID2167
GENE_SYMBOLFABP4
GENE NAMEfatty acid binding protein 4 adipocyte
SYNONYMNSaP2, ALBP, AFABP, A-FABP, HEL-S-104
CHROMOSOME8
HOMOLOGENE ID36067
microRNAsNANA
GENE SUMMARY
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small highly conserved cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake transport and metabolism. [provided by RefSeq Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. we found high serum A-FABP4 but unchanged RBP4 concentrations and their associations with renal function and early diabetic nephropathy in type 2 DM.18305958
Cardiovascular1. These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus.20920650
Atherosclerosis1. FABP4 up-regulation is responsible for the enhanced macrophage lipid accumulation by AGE, which may underlie the accelerated formation of foam cells and development of atherosclerotic cardiovascular diseases in diabetic patients.21336983
Retinopathy1. FABP4 shows potential as a novel biomarker for DR prediction in Chinese patients with T2DM, and strict glycaemic control and more frequent retinal examination should be highlighted for T2DM patients with the highest quartile range of FABP4.29305311