FABP5
LOCUS ID2171
GENE_SYMBOLFABP5
GENE NAMEfatty acid binding p
SYNONYMNSEFABP, KFABP, E-FABP, P
CHROMOSOME8
HOMOLOGENE ID108238
microRNAsNANA
GENE SUMMARY
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus.20920650
Atherosclerosis1. This study provides evidence for an additive relation of FABP4 and FABP5 with the metabolic syndrome, inflammatory cardiovascular disease risk factors, and corory atherosclerosis in type 2 diabetes mellitus20920650
Dyslipidemia1. The FABP5 plasma levels were positively correlated with adiposity, glucose metabolism, and lipolysis parameters and were associated with AD, as assessed by NMR.27055964