| FASN |
| LOCUS ID | 2194 | ||||||||||
| GENE_SYMBOL | FASN | ||||||||||
| GENE NAME | fatty acid synthase | ||||||||||
| SYNONYMNS | FAS, OA-519, SDR27X1 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 55800 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of DPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Oral treatment of ZQR improved diabetic nephropathy by inhibiting the overexpression of SREBP-1c and its target genes including ACC and FAS in experimental type 2 diabetic rats. | 22564814 |